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Vitamin B6


Vitamin B6 is required for the proper functioning of more than 60 different enzymes and is involved in the formation of body proteins and structural compounds, neurotransmitters, red blood cells, and prostaglandins. Vitamin B6 is also critical in maintaining hormonal balance and proper immune function. Deficiency of vitamin B6 is characterised by depression, convulsions, glucose intolerance, anaemia, impaired nerve function, cracking of the lips and tongue, and seborrhea or eczema.


For most indications the therapeutic dosage of vitamin B6 is 50mg-200mg.

Peripheral nerve disorders

A standard dose of 150mg has been suggested. Concerns regarding neuropathy in humans have become evident only when doses greater than 1g per day were given for the treatment of PMS, asthma, and certain sensory neuropathies.

Potential applications

PMS, depression, asthma, carpal tunnel syndrome, morning sickness, atherosclerotic heart disease, kidney stones, diabetes (peripheral nerve abnormalities), epilepsy, autism, immune function (AIDS), morning sickness, and sickle cell anemia. Low levels of vitamin B6 (as well as folic acid and vitamin B12) may contribute to osteoporosis as a result of an increase in homocysteine. Researchers in Japan have published studies suggesting that B6 deficiencies impair conversion of alpha-linolenic acid to EPA and DHA, with the most pronounced reduction in production of DHA.

Known contraindications

Pregnant and breast-feeding women should not take more than 100 mg of vitamin B6 per day without a doctor's supervision. High dose, long term vitamin B6 supplementation should not be undertaken without physician guidance.


The conversion of pyridoxine to its active form pyridoxine-5-phosphate (PLP) requires riboflavin, and magnesium. Corticosteroids may increase the loss of vitamin B6. Oral contraceptives have been associated with vitamin B6 depletion and clinical depression.

Use in conjunction with

  • PMS - Hemp seed oil, agnus castus, cal/mag/zinc


Alcoholism prevents the conversion of pyridoxine to its active form PLP.


© Cheryl Thallon at Viridian

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