Balanced Iron Complex

Iron

Iron plays a key role in the production of haemoglobin within our red blood cells (RBC), where it is required for oxygen transportation from the lungs to the body's tissues and the carbon dioxide transportation from the tissues to the lungs. Iron is also required for the synthesis of key enzymes in energy production and metabolism, including DNA synthesis.

ANAEMIA - Iron intake is frequently inadequate in four main groups:
1. Infants and young children
2. Adolescents in early growth spurt phase
3. Menstruating women
4. Pregnant women
Common symptoms of iron-deficiency include listlessness, fatigue, palpitations on exertion, sore tongue, angular stomatitis, dysphagia, anaemia, decreased serum iron, impaired capacity to maintain body temperature and decreased resistance to infection.
RESTLESS LEGS SYNDROME - Low iron stores can result in a condition called akathisia, a state of agitation. Studies have shown that low serum ferritin levels were reduced in those individuals with RLS, and that iron supplementation can produce a significant reduction in symptoms.
PHYSICAL PERFORMANCE - Iron deficiency is the most common deficiency in the western world, and it has been shown that even slight anaemia leads to a reduction in physical work capacity and productivity. Iron dependent enzymes are required for energy production and metabolism.
ANTIOXIDANT - Iron is required for antioxidant enzyme activation i.e. peroxidase, catalase, myeloperoxidase. These enzymes are protective against bacterial infection and the free radical effects of hydrogen peroxide, free hydroxy radicals and chloride ions.

Iron Bisglycinate is a gentle, non-constipating, chelated iron supplement that has been shown to be four times more bioavailable than the commonly prescribed ferrous sulfate. Additionally, iron bisglycinate does not irritate the gastrointestinal system and is non-constipating. Research has shown that iron bisglycinate has superior absorption and bioavailability and has been successfully used to treat difficult cases of anemia. The iron bisglycinate molecule is believed to be absorbed intact in a manner similar to amino acid absorption. This unique iron source allows for the use of less iron in a supplement owing to its excellent bioavailability. Supplementing with a lower dose of iron means fewer side effects and a reduced level of interactions with other minerals and nutrients.

You may also want to consult with your doctor about a carbonyl iron supplement, which can have fewer side effects than other sources of iron. Carbonyl iron is naturally regulated by the body, providing for a more gradual absorption. Many people find that it is a well-tolerated, milder alternative to other forms of iron.

Folic Acid

Folic acid functions together with vitamin B12 in maintaining healthy cell division and DNA synthesis.

RED BLOOD CELL PRODUCTION - Folic acid is required for healthy red blood cell division. A deficiency of folic acid can cause megaloblastic anaemia resulting in immature, enlarged cells often containing excessive haemoglobin.
CELLULAR PROTECTION - Folate deficiency is suspected in the initiation of cancer. Folate deficiency in cells and tissues is thought to increase the potential for neoplastic changes in normal cells during the early stages of cancer.

Vitamin B12

CELLULAR FUNCTION - Vitamin B12 works with folic acid in many body processes, including DNA synthesis, red blood cell production, and the production of myelin (insulation sheath surrounding nerve cells).
METHYL DONOR - Vitamin B12 like folic acid is a compound that carries and donates methyl groups (a molecule of one carbon and three hydrogen molecules) to other molecules, including cell membrane components and neurotransmitters. Vitamin B12 plays a critical role in proper energy metabolism and nerve function.

Vitamin C

IRON ABSORPTION - Vitamin C aids the absorption and utilisation of iron in the body. (See interactions)
ANTIOXIDANT - In addition to the synergistic effects of vitamin C and Iron, vitamin C also has a powerful antioxidant effect, helpful in counteracting any potential for pro-oxidation of free iron in individuals with cardiovascular risk. Vitamin C supplementation helps maintain blood GSH (glutathione) levels supporting antioxidant defences and maintaining the structural integrity of red blood cells.

Dosage

Maintenance dose - 15mg. In cases of deficiency and anaemia higher levels are recommended - up to 100mg daily. For individuals sensitive to ferrous sulphate divide the dose by 4 to reach iron bisglycinate daily amount. Regular assessment with a physician is recommended to avoid toxicity.

Potential applications

Conditions and populations associated with increased need for intake due to iron losses or impaired absorption are haemorrhage, protein calorie malnutrition, renal disease, achlorhydria, prolonged use of antacids, decreased GI transit time, steatorrhea, and parasites.

Known contraindications

Elevated levels of iron may lead to an increased risk of heart disease due to the pro-oxidative effect of free iron in the blood damaging cholesterol or the artery wall itself. Antioxidants such as vitamins C and E protect against iron-induced oxidative damage. Avoid in cases of haemachromatosis.

Interactions

Ascorbic acid (Vit C) can form a chelate with iron to aid its absorption. Vitamin C is also required for the release of iron from stores. Excessive intake of non-haem iron may have a detrimental effect on zinc absorption. Iron appears to accumulate in the liver and spleen with vitamin A deficiency, resulting in iron deficiency. Iron and LEAD also interact. Lead inhibits the activity of an enzyme required in haem synthesis. Additionally, increased lead absorption occurs with iron deficiency, especially in children.

Use in conjunction with

Anaemia - Ester-C, green food blend, EFAs, multi-vitamin/mineral, dong quai, magnesium and B6.

Note

The term haemochromatosis is used to indicate a genetic condition of iron overload or toxicity, which is coupled with tissue damage.

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