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GTF Chromium Complex

GTF or Glucose Tolerance Factor chromium was first isolated in brewer's yeast. This trivalent form was found to consist of chromium, vitamin B3 (nicotinic acid) and three amino acids. Other forms of chromium containing vitamin B3 (chromium polynicotinate), amino acids, yeast or other organic chelates such picolinic acid maximise bioavailability. Trivalent chromium has been shown to potentiate insulin and thereby influence carbohydrate, lipid and protein metabolism. Chromium is noted for its beneficial effects in weight control, type 2 diabetes, and reducing elevated blood fats (cholesterol, triglycerides).



Alpha Lipoic Acid


Current supplemental guidelines suggest up to 600mcg chromium per day. This dose would appear appropriate in cases of elevated blood lipids. Many experts in the field of nutritional medicine currently suggest 400-600mcg chromium for glycaemic disorders such as impaired glucose tolerance. Trivalent chromium, the form of Cr found in foods and nutrient supplements, is considered one of the least toxic nutrients. There have not been any reported toxic effects in any of the human studies involving supplemental Cr.

Potential applications

Weight control, Insulin resistance (Metabolic Syndrome), type 2 diabetes, hypoglycaemia, diabetes due to long term steroid use, peripheral neuropathy, atherosclerosis, elevated blood lipids, acne, weight loss.

Known contraindications

Chromium supplementation may enhance the effects of drugs for diabetes (e.g., insulin, blood sugar-lowering agents) and possibly lead to hypoglycemia. Therefore, people with diabetes taking these medications should supplement with chromium only under the supervision of a doctor.


Refined sugars, white flour products, and lack of exercise can deplete chromium levels. Calcium carbonate and antacids may reduce chromium absorption.

One study has demonstrated increased dream activity, greater vividness and colour in dreams, and diminished sleep requirements in those taking 50µg Cr daily, taken in the evening.

Use in conjunction with

  • Weight control - carnitine, CoQ10, milk thistle, fibre complex, multi-phytonutrient complex, EFAs.
  • Limit saturated fats. Increase plant foods. Maintain 1.5 litres water daily. Avoid processed refined foods. Daily aerobic exercise. Resistance training 2-3 times weekly.


The highly processed foods common in the Western diet, such as white sugar and white flour, are almost completely devoid of chromium, this may partly explain the widespread problem of glucose intolerance and glycaemic disorders.


© Cheryl Thallon at Viridian

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